Monday, March 7, 2011

Intervention for Patients with Depression

Breast Cancer Intervention Reduces Depression, Inflammation

A psychological intervention for newly diagnosed breast cancer patients with symptoms of depression not only relieves patients' depression but also lowers indicators of inflammation in the blood.
Those are the findings of a new study by researchers at the Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute (OSUCCC-James) and the Ohio State University Department of Psychology involving patients with stage II or III breast cancer.
Patients who received a psychological therapy that reduced stress and enhanced their ability to cope experienced significant relief of depressive symptoms. Moreover, that improvement was followed by a reduction in markers of inflammation.
"Previously, we knew that inflammation was associated with depression-like symptoms among cancer patients, and that both are problematic, but we did not know whether treating depression would affect inflammation," says co-author Barbara L. Andersen, professor of psychology and an OSUCCC-James researcher.
"Inflammation is considered to be a cancer promoting factor, and both depression and inflammation predict increased risk of cancer death."
Patients in the control group received only health and psychological assessments of their condition over the 12-month study period and showed no improvement in depression or inflammation indicators.
The findings are published online in the journal Psychosomatic Medicine.
"This study shows that by helping breast cancer patients with depression, they will also experience less inflammation," says study leader Dr. William E. Carson, III, professor in the division of surgical oncology and associate director for clinical research at the OSUCCC-James.
First author Lisa Thornton, a post-doctoral researcher in the Department of Psychology, noted that 25 to 30 percent of cancer patients experience significant symptoms of depression. "Our findings underscore the importance of including psychological interventions in the comprehensive care of cancer patients who experience significant distress," Thornton says.
The study's patients were participating in a larger clinical trial testing the effects of the same intervention on disease endpoints. Previously published findings showed that the intervention reduced the risk of breast cancer recurrence and death.
This follow-up study examined records from 45 patients who entered the trial with clinically significant symptoms of depression.
Twenty-three of the patients had been randomized to receive the psychological intervention plus the assessment. The remaining 22 patients received only the assessment, which consisted of a personal interview and questionnaires that evaluated mood, fatigue, health status and the influence of pain on quality of life. Blood samples were taken to assess inflammation levels, which were determined using counts of overall white blood cells and neutrophils, and the ratio of two categories of immune cells.
All patients were assessed upon starting the trial, then at four, eight and 12 months.
For the intervention, groups of eight to 12 patients and two psychologists met weekly for four months and monthly for eight months.
By the study's end, patients receiving the intervention showed significant declines in symptoms of depression, fatigue, and pain and in the markers of inflammation.
"Significant anxiety or depressive disorder symptoms are usually not recognized and might even be trivialized as a 'normal' response to cancer. However, those with clinical depression need treatment, as symptoms may not remit or even when they do, it can take months," Andersen says.
Funding from the American Cancer Society, a Longaberger Company-American Cancer Society Grant, a U.S. Army Medical Research Acquisition Activity Grant, the National Institute for Mental Health, and the National Cancer Institute supported this research.

Saturday, March 5, 2011

Life Insurance after Cancer

Cancer Survivors - Life Insurance Solutions

When you are diagnosed with cancer, you think it will be impossible ever to obtain life insurance to protect your family. While this is probably the case for treatment as soon as you have been cancer free for five years, you have few options.

 
Cancer Survivors
FOR IMMEDIATE RELEASE
PRLog (Press Release) – Mar 04, 2011 – When you are diagnosed with cancer, you think it will be impossible ever to obtain life insurance to protect your family. While this is probably the case for treatment as soon as you have been cancer free for five years, you have few options. At this point, buying life insurance is a challenge, but it is not impossible. Your chances of getting a policy in place will depend greatly on the type, stage and grade of cancer and your treatment plan. Other factors that the insurer will consider include the time elapsed since the last treatment, the outcome of treatment outcomes, and how recent was your last cancer monitoring.

Most insurers will follow the guidelines set forth by the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) database. This report contains information on nearly three million cancer patients. Oncologists, doctors and medical researchers across the United States to submit reports to the database and this database patients simply assigned a number. Insurance companies are then able to access information for subscription . It gives them the opportunity to examine patient demographics, morphology, diagnostic measures, treatment, first course, tumor sites, and monitoring procedures. This allows them to really assess the risk when insurance these patients.

For more details and a preview look here:
http://www.knowthecancer.com/cancer-survivors-life-insur ...

Life insurance companies know that the greatest risk of death after treatment with the first couple of years. This report allows the insurance company to find out what cancer is. If the patient has a good prognosis, usually cannot get insurance, a year or two. Often the insurance company will also examine the medical records and medical records of breast cancer survivor for seven years until the end of treatment. If the patient has a good prognosis at this stage, may request a reassessment and better insurance premiums. Most cancer survivors can get insurance five years cancer free.

Some cancers are very difficult to get coverage, while others have little effect on the transmission capacity. Most insurance policies do not allow someone who is currently in cancer treatment. This is due to the fact that during this period, the risk of death is greater. Once you have made the successful treatment of a life insurance company may add a surcharge, hereinafter referred to as "temporary flat extra" for several years, depending on the cancer and treatment. These supplements are automatically deleted after a certain period.

Candidates who have the most common and treatable forms of breast cancer, prostate cancer, testicular cancer and thyroid may be able to get a standard notation if certain conditions are met. Other cancers such as leukemia or colon cancer, you throw in a high-risk group.

Trying to get life insurance as a cancer survivor, there are certain things you can do to increase your chances, as follows:

1. Gather all your pertinent medical records before your application. This should include your first pathology report, medical records, and your treatment record. You want to give the insurer of the most complete information possible. This will reduce delays in obtaining coverage. If you do not have this information, they assume you're high-risk cases.

2. Make sure you follow precisely the doctor's treatment plan. Your insurance company will not be willing to provide coverage, unless you follow doctor's orders and make all your visits.

3. Be sure to get quotes from several insurers. Especially in this area, there is a wide price range.

4. If you are unable to obtain life insurance on your own, do not give up. Many companies offer insurance plans. Although more expensive, you might be able to get some coverage up this way.

5. You may also consider insurance to be ranked as a last resort. This type of policy, the death benefit is extended there is the politics. During the early years, they pay only nominal fees, and if some are dying of cancer, and then after a few years, pay the full face value.

Read "Know The Cancer" blog to know more about cancer now: http://www.knowthecancer.com

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Know The Cancer is a topic to gives facts causes cancers. This may elaborate different types of cancers; it gives details throughout the whole system either for men or women

Breast Cancer: The Fight Starts with You and Your Friends


Photo illustration by Tania Savayan
One in every eight American women will develop breast cancer at some point in her lifetime.
A frightening statistic? Absolutely.

And hopefully, you're not one of those women. But don't you wish there was more you could do than just hope? There is. The fight against breast cancer starts long before diagnosis: It starts right now. With you.
First, and perhaps most obvious, get regular breast exams. They're crucial to ensure that problems are caught early, when cancer is more easily treated.

Mammograms have attracted controversy but they're still the gold standard of prevention

Next, research shows that other positive lifestyle changes can make a big difference, too. What kind of changes? That depends on your age. The older you get, the more your breast cancer risk increases. So while in your 20s, you might adopt healthier eating habits and a solid exercise routine; at 40, you'd be smart to put an annual mammogram on your calendar.
Believe it or not, the everyday choices you make could help increase or decrease your risk of getting breast cancer. So we put together this guide, which shows you steps you can take — and should take — in your 20s, 30s, 40s, 50s and beyond. Our point? Every year, you've got to be more vigilant , because the little things that you can do could save your life.

20s and 30s

If you're a woman in your 20s or 30s, you're probably worried about climbing the career ladder and juggling the kids — not about cancer.
And for most, there's not much cause for alarm: The probability of a woman in her 20s developing breast cancer is one in 1,837, according to the American Cancer Society. (Men can get breast cancer, too, although it's about 100 times less common.)
Still, women in this age group should check their breasts for changes regularly. It's rare, but more than 11,000 women under 40 will be diagnosed with the disease this year. Younger women also tend to have more aggressive breast cancers than older women.
Start establishing good habits now and you'll lay the groundwork for a lifetime of healthy choices. Here are a few more things to keep in mind.
Know your family history. Women with a family history of breast cancer, especially in first-degree relatives (parent, sibling, child), have a higher risk of developing the disease. And don't forget about Dad: It's just as important to gather information about your father's side of the family. "Genetics are equally from the mother and the father," says Dr. Andrew Ashikari, co-founder of the Ashikari Breast Center at the Dobbs Ferry Pavilion of St. John's Riverside Hospital. Talk to your doctor about whether you're considered high risk; you may need to start cancer screening tests earlier than you'd think.
Get to know your breasts. Specialists agree that you should be aware of how your breasts normally look and feel; doctors suggest starting monthly breast self exams while in your 20s. "You might be the first (to pick up) some subtle change that someone else…might not be aware of," says Dr. Nancy Mills, an oncologist with the Memorial Sloan-Kettering Cancer Center in Sleepy Hollow. Symptoms like lumps, swelling, redness, nipple pain and discharges don't necessarily mean cancer, but they shouldn't be ignored. Get a professional evaluation as soon as possible.
Start getting clinical breast exams. The American Cancer Society recommends that women in their 20s and 30s have a clinical breast exam by a health professional at least every three years. Many get this test during annual check-ups with their gynecologist.
Drink less. Alcohol consumption is consistently linked with an increased breast cancer risk; one analysis of more than 40 studies indicates that two drinks a day may boost the average woman's risk by 21 percent.
Exercise more. There's growing evidence that physical activity can help protect you. Aim for at least three hours of aerobic exercise a week, says Dr. Anthony Cahan, chief of breast surgery at Northern Westchester Hospital in Mount Kisco. He notes that it's easier for younger women to build a regular exercise routine into their lives, one that will hopefully last for decades. "What I recommend to all of my patients, regardless of age, is find something … fun, so you're not dreading it every time you do it," he says.
Watch what you eat. The relationship between diet and cancer is unproven, but some studies have found that breast cancer is less common in countries that favor a low-fat diet. One tiny way to make a change? Start cooking with canola or olive oil, which are rich in the omega-3 fatty acids that are thought to provide some benefits, says Dr. Helen Pass, director of breast care at the Center for Advanced Surgery at Bronxville's Lawrence Hospital.
If you're having a baby, breastfeed. Research isn't conclusive, but some studies suggest that nursing may slightly reduce the breast cancer risk.

In your 40s

Now, you need to be more aware than ever about changes in your breasts, because the risk jumps significantly: The chance of a 40-year-old developing breast cancer in the next decade is 1 in 70. Here's what's critical at this age:
Get an annual mammogram. A government task force created controversy last year with the suggestion that women in their 40s don't need annual mammograms, contradicting the longtime standard rule of thumb. But the American Cancer Society and other prominent medical organizations still strongly urge women to get this test every year, starting at 40. "I see a lot of cancer in 40-year-olds," says Mills. "When they're mammographically detected, they're small and they're more curable." Bumping up clinical breast exams to once a year is advised, too.
Check your vitamin D level. Cahan points out that we're not getting the same sun exposure as in past decades because of fear of melanoma and aging effects of the sun. The result? "Women are finding out that they're vitamin D deficient all over the place," he says. Researchers are still looking into the therapeutic possibilities of vitamin D, but some studies indicate that higher levels of the "sunshine vitamin" may be linked to a lower cancer risk. One Canadian report published earlier this year in the American Journal of Clinical Nutrition found that women who took at least 400 international units of vitamin D every day slashed their breast cancer risk by 24 percent. A simple blood test can determine your total level; Cahan adds that women in their 40s — who may have taken vitamin supplements during their prime childbearing years — tend to slack off once they're done having kids.
Continue to eat right and exercise. Pass notes that women this age tend to neglect their health because they're too busy balancing work and a robust family life. "At 40, am I still exercising and eating right?" she says. "These are questions that we have to re-ask."

In your 50s and beyond

It's a fact, and one that many women don't know: The older you get, the greater your risk of developing breast cancer. The majority of breast cancer cases are in women over 50; the National Cancer Institute puts the median age of diagnosis at 61. So for postmenopausal women, careful screening is more important than ever. You should also:
Try to avoid or limit hormone replacement therapy. The average age of menopause is 52, and hormone replacement therapy used to be a standard treatment to help relieve hot flashes and other symptoms. That changed in 2002 when a landmark study by the Women's Health Initiative found that there is an increased risk of breast cancer (as well as heart disease, stroke and blood clots) associated with the use of estrogen and progestin (known as combined HRT). Yet the use of estrogen alone in the short-term seems to be OK in certain cases. "What you need is the lowest dose for the least amount of time," says Pass. Some specialists strongly discourage hormone use for high-risk women, noting that medications like certain anti-depressants can also ease menopause symptoms. Cahan, however, has no problem prescribing HRT if nothing else works. "There's a subset of women who, for them, menopause is holy hell," he says. "Sometimes you have to accept the risks for the quality of life improvement that it gives you."
Maintain a healthy weight, or lose some pounds. Diet and exercise are key, since adult weight gain and obesity clearly increases the breast cancer risk. One recent study found that losing at least 22 pounds after menopause — and keeping it off — lowered that risk by 57 percent. Age is no excuse for not staying active: "Walking is something you can do when you're 85," says Pass.
Make your yearly mammogram appointment. You are never too old for this test, but Mills says that she sees far too many older patients who believe the opposite. As long as a woman is in good health and a candidate for treatment (should cancer be detected), there's no reason to stop getting mammograms. "I see lots of 60- and 70-year-olds — and 80-year-olds — who are very effectively treated if early detected," says Mills. "We shouldn't lose sight of the older women whose lives can be saved by mammograms."

New Model to Determine What Prolongs Cancer Free Survival

U of L professor to create new statistical model for cancer research

Written By: Ash on March 5, 2011 0
A University of Louisville professor is developing a statistical model that, among other things, may help determine what prolongs cancer free survival.
Somnath Datta, PhD, a professor in the Department of Bioinformatics and Biostatistics at the UofL School of Public Health and Information Sciences, and his team will incorporate medical and genomic data into the statistical model to find better answers to scientific questions.
A statistical model describes how one or more random variables relates to other variables. A multi-state model, which is the type Datta and his team are developing, looks at process – for example, how a person, moves from one state to another over a period of time.
For someone with cancer, the model could analyze how the disease progresses from one stage to another. Or, for a patient in remission, the model might help determine what prolongs cancer free survival. Datta could incorporate all these factors into his statistical model.
The new statistical model will allow for broad inspection of patient patterns and data collection that are more practical.
“The model will be derived from empirical evidence – based on observation or experience – rather than unverifiable mathematical laws,” Datta said. “As a result, the prediction from the methodology will be more robust and less likely to include model misspecification errors.”
In addition to having applications to cancer research, the new statistical method will be applicable to many other disciplines ranging from engineering to political science that deal with staged systems – or any system that can transition from one phase or stage to another. In politics, for instance, this would involve all the elements from planning a campaign to taking office.
Datta recently received a two year grant from the National Security Agency (NSA) under the Mathematical Sciences Program for this project. Work is expected to begin this month.
Source: University of Louisville
http://biomedme.com/general/uofl-professor-to-create-new-statistical-model-for-cancer-research_36757.html

Friday, March 4, 2011

Journey Beyond Breast Cancer-Poetry

Poetry Friday

Kamilah, Kahlil's mother. Painting by Kahlil Gibran
On Joy and Sorrow
Your joy is your sorrow unmasked.
And the selfsame well from which your laughter rises was oftentimes filled with your tears.
And how else can it be?
The deeper that sorrow carves into your being, the more joy you can contain.
Is not the cup that holds your wine the very cup that was burned in the potter’s oven?
And is not the lute that soothes your spirit, the very wood that was hollowed with knives?
When you are joyous, look deep into your heart and you shall find it is only that which has given you sorrow that is giving you joy.
When you are sorrowful look again in your heart, and you shall see that in truth you are weeping for that which has been your delight.
Some of you say, “Joy is greater thar sorrow,” and others say, “Nay, sorrow is the greater.”
But I say unto you, they are inseparable.
Together they come, and when one sits, alone with you at your board, remember that the other is asleep upon your bed.
Verily you are suspended like scales between your sorrow and your joy.
Only when you are empty are you at standstill and balanced.
When the treasure-keeper lifts you to weigh his gold and his silver, needs must your joy or your sorrow rise or fall.
Kahlil Gibran

Helping to fund Cancer Research






It's one thing to raise money for cancer, but it's quite another to figure out how the money is 


being spent or wasted.


During the time when I was trying to make sense of my diagnosis, I had a disturbing thought. What about all those "walks" for breast cancer? What about all the money I poured into those organizations over the past 20 years? Where's my payback? Would it be the drug that would make this all go away?

For years, there has been no transparency, no accountability and no collaboration. Scientists and universities had their eye on the prize - The Nobel prize that is, and so they worked very secretively in silos, never sharing any of the advances they discovered.

That is why I chose UCLA and my doctor, Dr. John Glaspy and Dr. Dennis Slamon. At The time, UCLA was one of the few universities sharing information. The colon cancer scientists worked right next to the pancreatic scientists and so on. When one drug turned out to be a dead end for a certain cancer, they would walk it across the hall to let the breast cancer researchers have a go at it. In fact, a promising new drug for breast cancer failed in trials and was turned over to colon cancer and is now the state of the art drug for colon cancer patients.

Recently, we had a board meeting for The Noreen Fraser Foundation. Dr. Glaspy presented a PowerPoint presentation on exactly how the NFF money was being used, the advances made to date because of our money and the breakthrough drug they hope to have ready for clinical trials this year. This drug would be for breast cancer patients. It is a non-toxic drug that will replace certain chemo drugs.

I can't tell you how good it feels to know exactly how all of your hard work is paying off. As Dr. Glaspy said to our group, "fighting cancer is a team effort. Activists and patients committed to change and expand the research agenda is exactly what the field of cancer needs." And he's right. 

Friday is my day of reckoning. I will have a PET scan to see if the toxic chemo I have been taking for eight weeks has made a difference in the size of the tumors in my liver. If it has, I will continue on with this regimen of Xeloda and try to deal with the side effects.

My hands are beet red, swollen and blistered. The bottom of my feet are red hot, and with every step I take, I feel like I am walking over hot coals. I lather up every night with cream and wear socks and gloves to bed. Very sexy! The good news is that this chemo does not make your hair fall out and my hair has never looked better - from the boobs up, I look pretty darn hot!

Time is of the essence for those of us waiting for the development of new non-toxic treatments. The government money has dried up for cancer research and the economic climate has affected foundation giving to cancer research. It comes down once again to the commitment of individuals. We can make a difference - and we will. 

Noreen Fraser is living with Stage IV metastatic breast cancer. She is co-founder of STAND UP TO CANCER and co-produced the TV show, which raised 100 million dollars for cancer research. The 'Men for Women Now' program enlists men to ask the women they love to make appointments for their mammogram and pap smear. Noreen can be reached at noreen@noreenfraserfoundation.org.

Tuesday, March 1, 2011

Colon Cancer Support

Right Scan Right Time Featured Ambassador: Erika Hanson Brown, Colorado

Erika Hanson Brown - Right Scan Right Time Featured AmbassadorWhen Erika Hanson Brown was going through colon cancer eight years ago, she often felt alone in navigating her treatment and staying connected with others, especially locally in Denver where she lives. Six months into treatment, she decided to ditch her “passive patient” mentality and became a committed advocate to her fight with cancer, networking with others who had a similar diagnosis, researching resources and seeking second opinions.
That mentality led Erika to found ColonTown, a patient advocacy network that connects patients at a local, disease-specific level to ultimately create a “village of resources” for colon cancer patients. ColonTown is unique because it creates a community not only for those going through colon cancer, but also for those who successfully have gone through treatment, encouraging them to stay involved in the community, continuously learning and serving.
Colontown
How does it work? Everyone diagnosed with colon cancer becomes a “colonist” in ColonTown. People begin to assume roles in the community and hold community meetings, either online or in person.
“Most people feel like they have a wonderful support network of family and friends, but what’s lacking is a local connection to someone going through colon cancer specifically,” said Erika. “Colonists know the specific language of colon cancer, they may know about new treatments, and they know the personal journey that only colon cancer survivors go through.”
Most importantly, ColonTown creates continuity; “It’s like a circle,” said Erika. “In addition to helping those going through treatment, ColonTown addresses the drop-off point when people are done with cancer. They suddenly stop seeing the supportive community they had while going through treatment and are left feeling high and dry. This is a critically important point because while colon cancer survivors no longer receive routine treatment, they must receive routine imaging to catch any recurrences early.”
ColonTown seeks to mobilize these survivors, and make sure they stay current when those resources start to disappear.
“When I was going through colon cancer, I was just lucky,” said Erika. “I want people to be more than that - to be smart and have the resources to advocate for themselves.
To learn more about ColonTown or become a Colonist, visitwww.facebook.com/colontown